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Binjiang Fine-chemical Park,
Xinbei District, Changzhou 213127
Jiangsu, China
Contact Person
Linda He
Tel: 0519-88122965 13775180513
Email: linda@huarenchem.com
Cao Jing
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Email: info@huarenchem.com
Amy Zhou
Tel: 0519-88103998 13646148298
Email: amy.zhou@huarenchem.com
Miss Yu
Tel: 0519-88100916 13775081323
Email: ylp@huarenpharm.com
Fax: ++86 519 8810 4456

Products | APIs

Product Name

Sirolimus

CAS#

53123-88-9

Synonyms

Rapamycin

中文名

雷帕霉素; 西羅莫司

Molecular Formula

C₅₁H₇₉NO₁₃

Description

Biochem/physiol Actions

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Properties

biological source	from Streptomyces hygroscopicus
sterility	0.2 μm filtered
assay	≥95% (HPLC)
concentration	2.5 mg/mL in DMSO (2.74 mM)
EQP level	Premium
storage temp.	−20°C

Safety

Personal Protective Equipment	Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
WGK Germany	1
UEL	42.00%
LEL	3.50%
Flash Point(F)	189 °F
Flash Point(C)	87 °C

Notice

Products protected by valid patents in this list are for laboratory analytical / research purposes only and are not offered for sale in countries where the sale of such products constitutes a patent infringement, its liability is at buyer's risk!